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Therapies to Remember
 

Literature On Our Programs

 
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Microglia

Microglia in Neurodegeneration (Nat Neurosci. 2018)


Progranulin

Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis. (J Neurol. 2015)

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. (Mol Neurodegener. 2014)

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease. (Gene. 2014)

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. (Neuron. 2010)

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. (J Exp Med. 2010)

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. (Nature. 2006)


TREM2

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (Cell. 2017)

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. (Immunity. 2017)

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. (EMBO Rep. 2017)

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. (Neuron. 2016)

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. (Cell. 2015)

TREM2 and neurodegenerative disease. (N Engl J Med. 2013)

TREM2 variants in Alzheimer's disease. (N Engl J Med. 2013)


SIGLEC 3

CD33 in Alzheimer's disease. (Mol Neurobiol. 2014)

CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. (J Neurosci. 2013)

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. (Neuron. 2013)

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. (Nat Neurosci. 2013)