Microglia

Microglia in Neurodegeneration (Nat Neurosci. 2018)

Progranulin

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice (Mol Neurodegener. 2018)

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C. (J Neurochem. 2017)

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access (J Neurochem. 2017)

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin (J Cell Biol. 2015)

Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis. (J Neurol. 2015)

Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. (Mol Neurodegener. 2014)

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease. (Gene. 2014)

Progranulin regulates neuronal outgrowth independent of Sortilin (Mol Neurodegener. 2012)

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. (Neuron. 2010)

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy (PLoS ONE 2010)

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. (J Exp Med. 2010)

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. (Nature. 2006)

TREM2

TREM2 function impedes tau seeding in neuritic plaques. (Nat Neurosci. 2019)

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (Cell. 2017)

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. (Immunity. 2017)

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. (EMBO Rep. 2017)

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese. (Neurobiol Aging. 2016)

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. (Neuron. 2016)

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. (Cell. 2015)

TREM2 and neurodegenerative disease. (N Engl J Med. 2013)

TREM2 variants in Alzheimer's disease. (N Engl J Med. 2013)

SIGLEC 3

CD33 in Alzheimer's disease. (Mol Neurobiol. 2014)

CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. (J Neurosci. 2013)

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. (Neuron. 2013)

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. (Nat Neurosci. 2013)